The Duomo complex rises in the heart of Florence's historic center, on Piazza del Duomo, with the Cathedral's distinctive dome visible from across the city. Its central location makes it easily accessible on foot from most landmarks, and the area is served by local buses and taxis. Streets around the square are largely pedestrianized, allowing visitors to move between the monuments safely and enjoy the surrounding Renaissance architecture at a leisurely pace.
The Duomo complex, including the Cathedral, Dome, Baptistery, Bell Tower, and Museum, is situated at Piazza del Duomo in the historic heart of Florence.
Yes, there are several bus stops near the Duomo that allow visitors to reach it comfortably. The Duomo is also withing walking distance of the main train station, Santa Maria Novella (about 15 mins).
Most of the city center of Florence is restricted to cars without a special permit, so the best option would be to find the nearest accessible car park and walk to the Duomo from there.